1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(hydroxymethyl)-, phenylmethyl ester
3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine
CAS: 1255099-67-2
Molecular Formula: C18H26N2O5
1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(hydroxymethyl)-, phenylmethyl ester - Names and Identifiers
1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(hydroxymethyl)-, phenylmethyl ester - Physico-chemical Properties
| Molecular Formula | C18H26N2O5 |
| Molar Mass | 350.40944 |
| Density | 1.22±0.1 g/cm3(Predicted) |
| Boling Point | 510.5±50.0 °C(Predicted) |
| pKa | 12.01±0.40(Predicted) |
| Storage Condition | 2-8°C |
1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(hydroxymethyl)-, phenylmethyl ester - Upstream Downstream Industry
| Downstream Products | 6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE |
1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(hydroxymethyl)-, phenylmethyl ester - Introduction
3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine is an organic compound with the following properties:
1. Appearance: white crystalline solid
2. Molecular formula: C17H24N2O5
3. Molecular weight: 340.38g/mol
4. Melting Point: 95-102 ° C
5. Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dichloromethane
The compound is commonly used in pharmaceutical synthesis and organic synthesis. It is an important protecting group that can be used to protect amino and hydroxyl groups to avoid non-selective reactions during the reaction. It can be used as an intermediate in the pharmaceutical field to synthesize various bioactive molecules. In addition, it can also be applied to the synthesis of functional compounds and heterocyclic compounds.
The method for preparing the compound is as follows: 3-carboxycaprolactone is obtained by reacting hydroxymethylpyrrolidine with caprolactone in the presence of sodium 3-cyanopropionate. 3-carboxycaprolactone is reacted with tert-butoxycarbodiimide and a sodium salt of an organic base to give tert-butoxycarbonylcaprolactone. Then, tert-butoxycarbonylcaprolactone is reacted with methanol and HCl or H2SO4 to produce tert-butanol hydrochloride. Finally, the target compound is produced by reacting tert-butanol hydrochloride with methylbenzylamine.
For safety information about this compound, the following matters need to be noted:
1. When handling and handling the compound, wear appropriate protective gloves and glasses to avoid contact and inhalation.
2. The compound may be irritating and damaging to the eyes, skin and respiratory system.
3. When storing and handling the compound, follow safe operating procedures and keep away from open flames and high temperatures.
4. When using the compound in the laboratory, ensure that the operating environment is well ventilated.
1. Appearance: white crystalline solid
2. Molecular formula: C17H24N2O5
3. Molecular weight: 340.38g/mol
4. Melting Point: 95-102 ° C
5. Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dichloromethane
The compound is commonly used in pharmaceutical synthesis and organic synthesis. It is an important protecting group that can be used to protect amino and hydroxyl groups to avoid non-selective reactions during the reaction. It can be used as an intermediate in the pharmaceutical field to synthesize various bioactive molecules. In addition, it can also be applied to the synthesis of functional compounds and heterocyclic compounds.
The method for preparing the compound is as follows: 3-carboxycaprolactone is obtained by reacting hydroxymethylpyrrolidine with caprolactone in the presence of sodium 3-cyanopropionate. 3-carboxycaprolactone is reacted with tert-butoxycarbodiimide and a sodium salt of an organic base to give tert-butoxycarbonylcaprolactone. Then, tert-butoxycarbonylcaprolactone is reacted with methanol and HCl or H2SO4 to produce tert-butanol hydrochloride. Finally, the target compound is produced by reacting tert-butanol hydrochloride with methylbenzylamine.
For safety information about this compound, the following matters need to be noted:
1. When handling and handling the compound, wear appropriate protective gloves and glasses to avoid contact and inhalation.
2. The compound may be irritating and damaging to the eyes, skin and respiratory system.
3. When storing and handling the compound, follow safe operating procedures and keep away from open flames and high temperatures.
4. When using the compound in the laboratory, ensure that the operating environment is well ventilated.
Last Update：2024-04-09 21:00:56
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Product Name: 3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine Visit Supplier Webpage Request for quotation
CAS: 1255099-67-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1255099-67-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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